[Skip to Content]
[Skip to Content Landing]
Other Articles
February 1925


Author Affiliations

From the Division of Contagious Diseases, Cleveland City Hospital, and the Department of Pediatrics, Western Reserve University.

Am J Dis Child. 1925;29(2):214-220. doi:10.1001/archpedi.1925.04120260062007

In 1917, Fonde1 reported a case of malignant diphtheria, treated by massive doses of antitoxin given intraperitoneally. In November, 1921, Goehle and Dauer2 from this hospital reported five additional cases, treated intraperitoneally with diphtheria antitoxin mixed with saline solution, a procedure initiated, because one of the authors had the impression that antitoxin given intravenously in patients severely ill, was followed often by serious results. Recently Platou3 published his observations on twelve cases of diphtheria treated in the same way, but with a specially made globulin antitoxin mixed with saline solution. In the last year, fifty cases of diphtheria have been treated with commercial antitoxin, injected intraperitoneally without the admixture of saline solution. We are reporting these cases and are comparing them with 100 other cases of diphtheria; fifty of the patients were treated with intramuscular and fifty with intravenous injection of diphtheria antitoxin.

Chart 1 shows the