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April 1925

THE KIDNEY: A FILTER FOR BACTERIA: II. THE EFFECT OF DIURESIS ON THE EXCRETION OF BACTERIA BY THE KIDNEY

Author Affiliations

Laboratory Assistant, Section on Pediatrics, Mayo Clinic ROCHESTER, MINN.

Am J Dis Child. 1925;29(4):506-512. doi:10.1001/archpedi.1925.04120280076006
Abstract

Biedl and Kraus, in their experiments on the excretion of bacteria by the normal kidney, used a preliminary intravenous injection of glucose in order to stimulate the flow of urine. Since their experimental results differ from those of many others, as well as from our own, it occurred to us that possibly the added rapidity of secretion produced by the intravenous injection might be responsible for the results obtained. We, therefore, undertook a series of experiments, using hypertonic glucose and sodium chlorid solution to promote diuresis. The urine was obtained by the standard technic employed in all of our experiments; namely, by using a single rabbit for each experiment and securing the urine with a sterile pipet from the seared bladder of the chloroformed rabbit. The one objection to this method is that it is impossible to control the flow of urine, and that all the urine excreted in the

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