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May 1925


Author Affiliations

From the Pediatric Department, Harvard Medical School, and the Children's Hospital.

Am J Dis Child. 1925;29(5):631-640. doi:10.1001/archpedi.1925.04120290052008

REVIEW OF THE LITERATURE  Previous to the description by Morse,1 in 1898, there is but little reference in the literature regarding those primary blood diseases in children which are now recognized as leukemia. Morse was able to find only seven. Churchill,2 even as late as 1904, collected only twenty-two cases, including the seven reported by Morse. Analysis of these early cases shows that little attempt was made to classify them into the groups which are now authentically established. As the result of increasing knowledge and steady improvement in the technic of routine blood examination, the number of cases reported has materially increased until leukemia is no longer considered a rare disease in children. In 1910, Ribadeau-Dumas and Boudet3 reported a series of 100 cases of acute leukemia, nineteen of which were in children. In 1922, Morse4 reported thirty-seven cases of severe anemia which he had seen

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