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May 1925

THE KIDNEY: A FILTER FOR BACTERIA: IV. THE EFFECT OF CLAMPING THE RENAL ARTERY OR RENAL VEIN ON THE PASSAGE CF BACTERIA INTO THE URINE

Author Affiliations

Laboratory Assistant, Section on Pediatrics, Mayo Clinic ROCHESTER, MINN.

Am J Dis Child. 1925;29(5):645-649. doi:10.1001/archpedi.1925.04120290070010
Abstract

The negative results obtained in previous experiments in attempting to force bacteria through the kidney by diuresis led us to investigate further the powers of the kidney to hold back bacteria when subjected to various injuries. In this series of experiments, the left renal artery or vein was clamped for varying periods of time and at the same time the right ureter was tied, so that no urine could reach the bladder from the normal kidney. The bladder urine was always tested for sugar, to make sure that there had actually been a secretion of urine from the injured kidney. To insure a secretion of urine whenever possible, a 20 per cent, sucrose solution was injected intravenously. The tremendous diuretic effect of the sucrose is best seen in the markedly hydronephrotic kidneys that were produced in less than an hour; and is evidenced by the fact that in the experiments

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