The use of insulin in the treatment of malnourished infants was first suggested by Pitfield1 in 1923. He considered that beneficial effects were obtained in two cases by the daily administration of 1 unit of insulin, given at the same time as the morning feeding. In 1924, Marriott2 concluded that the nutrition of malnourished infants might be rapidly improved by intravenous injections of glucose and insulin. Barbour,3 as the result of Marriott's work, administered insulin to forty nondiabetic malnourished children. The nutrition of thirty-eight of the forty was benefited. Twenty-three of the children had accompanying infectious conditions, which were also improved. All of these observers concluded that considerable benefit was derived from the injections. However, in none of the foregoing three papers were any blood sugar determinations reported.
Two years ago, in this clinic, insulin was administered to malnourished infants but no beneficial results were detected. The
FREDERICK F. TISDALL, ALAN BROWN, T. G. H. DRAKE, M. G. CODY. INSULIN IN THE TREATMENT OF MALNOURISHED INFANTS. Am J Dis Child. 1925;30(1):10–18. doi:10.1001/archpedi.1925.01920130016002