In former experiments on rabbits, the complete failure to change the kidney so as to make it possible for bacteria in the circulation to pass readily into the urine, led us to try the effects of certain substances toxic to the kidney. The effects of mercuric chlorid and uranium acetate on the epithelium of the kidney, and of cantharidin on the glomeruli, were tested. It did not seem likely that injury to the epithelium would change the permeability of the kidney for bacteria, but it was possible that changes might occur in the endothelial lining of the capillaries, which would allow bacteria to pass rapidly into the urine.
TECHNIC
The toxins were allowed to act from twenty-four to forty-eight hours before the bacteria were given intravenously to the animals, and then a period from two to twenty-four hours elapsed before they were chloroformed. The technic for obtaining the urine was