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July 1925

THE ANTIRACHITIC ACTION OF COD LIVER OIL: COMPARISON OF FRESH OIL WITH CONCENTRATE PREPARED FROM OIL

Author Affiliations

NEW YORK
From the Biochemical Department of the H. A. Metz Research Laboratories. Presented at the Ithaca meeting of the American Chemical Society, Sept. 8-13, 1924.

Am J Dis Child. 1925;30(1):72-75. doi:10.1001/archpedi.1925.01920130078012
Abstract

In a previous publication,1 the preparation, from cod liver oil, of a concentrate possessing the same antirachitic and antiophthalmic activity as the oil from which it was made was described. Extended observation over a long period of time has proved definitely that this cod liver oil concentrate is as effective in children as in animals.2

The present publication reports the results of experiments initiated for the purpose of establishing a quantitative relationship between the cod liver oil concentrate and the fresh oil. At the same time, I planned to determine the minimal quantity of cod liver oil which would protect rats against rickets when fed on a given rickets-producing diet.

Accordingly, young rats were placed on the Pappenheimer-Zucker Diet D3 for a period of thirty days. During this time, one group of rats received daily doses of varying quantities of fresh cod liver oil. Another group was

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