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August 1925


Am J Dis Child. 1925;30(2):210-218. doi:10.1001/archpedi.1925.01920140070006

Recent investigations concerning the etiology of infantile tetany have resulted in one definite conclusion, namely, that the blood calcium is markedly reduced during the active stage. This was first suggested by the experiments of Sabbatini,1 and was proved finally by the accurate estimations of Howland and Marriott.2 Earlier investigations by MacCallum and Voegtlin3 had shown a similar decrease in the calcium content of the blood in experimental parathyroid tetany in dogs. These results have been confirmed by the subsequent work of other authors, both in experimental tetany and in infantile tetany. Another fact generally conceded is that the inorganic phosphorus content of the blood is usually either normal or elevated.

The work presented here was carried out in order to determine whether a concomitant lowering of the calcium content occurred in the cerebrospinal fluid in infantile tetany and, also, to determine if there was an increase in

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