[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Other Articles
August 1925


Author Affiliations


Am J Dis Child. 1925;30(2):224-231. doi:10.1001/archpedi.1925.01920140084008

REVIEW OF THE LITERATURE  A certain train of symptoms affecting infants and young children has recently been designated as "acrodynia." In 1919, Bilderback1 reported ten cases of this condition in children presenting peculiar nutritional, neurologic and dermatologic disturbances. These case reports were sent to Dr. John Morse who, recognizing findings suggestive of pellagra, in turn referred them to Dr. Weston of Columbia. After careful study, Weston2 decided that the condition was not pellagra and applied the name acrodynia to the disease. In 1920, Byfield3 reported a series of seventeen cases presenting similar symptoms. Being impressed with the neurologic findings, he entitled his report "A Polyneuritic Syndrome Resembling Pellagra-Acrodynia?' His report was so complete that but little has been added by numerous later reports. In 1921, Brown4 reported eight typical cases. After careful clinical and metabolic studies, he concluded that acrodynia was not a deficiency disease, but