From clinical observation, we learn that several diseases at a certain period in their course have a retarded pulse rate. This slow pulse rate is perhaps best seen in cases of tuberculous meningitis in the stage of "irritation," attributed to the increased intracranial pressure. Similarly, we frequently observe a low pulse rate in other forms of meningitis, in brain tumors, in hydrocephalus and in intracranial hemorrhage. The slow pulse rate in these conditions has usually been assigned to an irritation of the vagus nerve or vagus center, for we know that stimulation of the vagus nerve causes a slowing of the heart beat. Very remarkable also is the slow pulse rate we sometimes see in the postcritical period of lobar pneumonia and in diseases characterized by icterus. The number of examples can easily be increased. Frequently, this slow pulse rate is associated with a subnormal temperature.
Is irritation of the
SCHICK B, COHEN P. IN POSTINFECTIOUS STAGES AND IN DISEASES CHARACTERIZED BY SLOW PULSE RATE: PRELIMINARY REPORT. Am J Dis Child. 1925;30(3):291–309. doi:10.1001/archpedi.1925.01920150007001
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