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September 1925


Author Affiliations

From the Milwaukee Children's Hospital.

Am J Dis Child. 1925;30(3):321-327. doi:10.1001/archpedi.1925.01920150037003

It has been known for many years that under certain conditions nitrites could be found in the urine. They have been detected in the urine of patients suffering from osteomalacia, gastro-intestinal catarrh, sulphhemoglobinemia, bacilluria and pyuria, and have been regarded as of diagnostic value in these diseases. Weltmann1 has recently reported that a positive reaction for nitrites in urine freshly passed constituted a reliable sign of urinary tract infection. No nitrites were found in normal fresh urine. A positive nitrite test indicated in a very simple manner without microscopic or bacteriologic examination that there was bacterial activity in the urinary tract. Positive results were obtained only when the bacterial invaders were nitrate-reducing organisms. Lowenstein2 also found the nitrite test to be of diagnostic value in bacilluria due to nitrate-reducing organisms, of which the commoner ones were B. coli, B. lactis aerogenes, B. proteus vulgaris and staphylococci. When the