It has been known for many years that under certain conditions nitrites could be found in the urine. They have been detected in the urine of patients suffering from osteomalacia, gastro-intestinal catarrh, sulphhemoglobinemia, bacilluria and pyuria, and have been regarded as of diagnostic value in these diseases. Weltmann1 has recently reported that a positive reaction for nitrites in urine freshly passed constituted a reliable sign of urinary tract infection. No nitrites were found in normal fresh urine. A positive nitrite test indicated in a very simple manner without microscopic or bacteriologic examination that there was bacterial activity in the urinary tract. Positive results were obtained only when the bacterial invaders were nitrate-reducing organisms. Lowenstein2 also found the nitrite test to be of diagnostic value in bacilluria due to nitrate-reducing organisms, of which the commoner ones were B. coli, B. lactis aerogenes, B. proteus vulgaris and staphylococci. When the
GREENTHAL RM. NITRITURIA. Am J Dis Child. 1925;30(3):321–327. doi:10.1001/archpedi.1925.01920150037003
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