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October 1925


Author Affiliations

From the Department of Pediatrics, Washington University School of Medicine, and the St. Louis Children's Hospital.

Am J Dis Child. 1925;30(4):476-482. doi:10.1001/archpedi.1925.01920160030002

It is a matter of common knowledge that ketosis is of frequent occurrence in children, and that it accompanies a variety of clinical conditions, including some of minor nature. It has been especially noted that certain infections of the respiratory tract lead to ketonuria. Frew,1 using the delicate nitroprussid reaction on the urines of a large number of unselected hospital patients, found the reaction positive in a considerable proportion. He considered the ketosis due to metabolic factors which were independent of any particular disease per se. Roberts2 noted a high incidence of ketosis in children suffering from respiratory infections, although he also found ketosis to be present in a wide variety of conditions.

The nitroprussid reaction on the urine is so extremely delicate that a positive test does not necessarily indicate ketosis of a significant degree. The ferricchlorid test is less delicate, and when positive is of greater