In the great amount of literature that has been contributed in the past decade to the study of rickets, scant attention has been directed to the consideration of a susceptibility or predilection to the disease. It has been observed in practice that under similar and favorable conditions one of several infants will be more susceptible to the disease than another, or, possibly, that one infant will show evidences of the disorder in a more severe grade than another. What constitutes this difference in susceptibility?
Howland and Kramer1 have shown that in rickets the inorganic phosphorus content of the serum is lower than in the normal. A low inorganic phosphorus concentration in the serum of some children at birth has been noted, and we have endeavored to see whether we can correlate this decrease in phosphorus with an increase in susceptibility to rickets.
The work was undertaken at Harlem Hospital,
RIESENFELD EA, HANDELMAN I, ROSE AR. INORGANIC PHOSPHORUS IN THE BLOOD OF THE NEW-BORN: ITS SEASONAL VARIATION AND ITS RELATION TO RICKETS. Am J Dis Child. 1925;30(5):646–658. doi:10.1001/archpedi.1925.01920170050004
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