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November 1925

INTRAPERITONEAL TRANSFUSION OF CITRATED BLOOD: THE EFFECT OF AN INTRAPERITONEALLY PRODUCED PLETHORA ON THE HEMOPOIETIC ACTIVITY OF THE BONE MARROW

Author Affiliations

ST. PAUL
From the Departments of Pediatrics and Pharmacology, University of Minnesota Medical School.

Am J Dis Child. 1925;30(5):659-666. doi:10.1001/archpedi.1925.01920170063005
Abstract

In a previous paper,1 an attempt was made to show experimentally the fate of citrated blood when it was injected into the peritoneal cavity. This work was done on a large series of rabbits. Necropsies at various intervals showed that absorption was usually completed in about five hours. In a similar series in which blood studies were made, there was a corresponding increase in hemoglobin and in red blood cells. To show conclusively that the red blood cells actually entered the circulation, pigeons were exsanguinated and the citrated pigeons' blood was injected into the peritoneal cavity of rabbits with the consequent recovery of the foreign, elongated, nucleated pigeons' corpuscles in the rabbits' circulation within fifteen minutes. Subsequently, Ruh and McClelland,2 and Opitz and Metes3 have also shown experimentally that when whole, citrated and defibrinated blood is injected into the abdominal cavity, it is absorbed quantitatively into the

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