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December 1925


Author Affiliations

From the Kingston Avenue Hospital of the Bureau of Hospitals, Department of Health, New York City, Dr. Frank J. Monaghan, Commissioner, S. B. Wynne, Director, and Dr. Donald D. Campbell, Physician in Charge.

Am J Dis Child. 1925;30(6):844-850. doi:10.1001/archpedi.1925.01920180104010

Guillain, Laroche and Lechelle1 have published the description of a new test of the cerebrospinal fluid called the colloidal benzoin reaction, which they have found of more precise value in the diagnosis and prognosis of syphilitic disease of the central nervous system than either the gold chlorid or the mastic test.

This colloidal reaction has, according to the originators of the method, several obvious advantages over the gold chlorid test. Thus, the reading of the results are more simple, as it is a question of a precipitation and not of a color change. Then again the suspension of benzoin is very simple to prepare, avoiding the technical difficulties so often encountered in the preparation of a reliable colloidal gold solution. Finally, a fact of great importance, is that reactions occurring in Tubes 1 to 5 are strictly limited to syphilitic disease of the central nervous system (with the exception of