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April 1926

THE RESPIRATORY METABOLISM IN INFANCY AND IN CHILDHOOD: III. GLYCOGEN STORAGE IN CHILDREN

Author Affiliations

NEW YORK
From the Department of Pediatrics, Cornell University Medical College and the New York Nursery and Child's Hospital.

Am J Dis Child. 1926;31(4):496-503. doi:10.1001/archpedi.1926.04130040039007
Abstract

This investigation was undertaken to study certain phases of the mechanism of glycogen storage in children. More specificially, it attempts to answer the following questions: 1. How much carbohydrate is mobilized for oxidation from the body stores of normal children during a given period of fasting under resting conditions? 2. Is the quantity different in children with cyclic vomiting under similar experimental conditions? 3. Does diabetes mellitus in children affect the capacity for glycogen storage?

A review of the literature reveals few previous attempts to measure accurately by means of the respiratory exchange the quantity of carbohydrate oxidized by children during fasting. Hasselbalch,1 Bailey and Murlin2 and Benedict and Talbot3 independently observed high respiratory quotients in new-born infants during the first few hours of life, indicating the oxidation of stored glycogen. The rapid depression of the quotients thereafter signified an early exhaustion of the glycogen reserves. At

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