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July 1927

RESPIRATORY ANAPHYLAXISSENSITIZATION, SHOCK, BRONCHIAL ASTHMA AND DEATH INDUCED IN THE GUINEA-PIG BY THE NASAL INHALATION OF DRY HORSE DANDER

Am J Dis Child. 1927;34(1):23-52. doi:10.1001/archpedi.1927.04130190030002
Abstract

Several years ago, one of us1 studied a group of children suffering from bronchial asthma, the cause of which was traced to rabbit hair. In none of these cases was it possible to obtain any hereditary evidence of protein sensitivity; the opinion was therefore expressed at that time that the sensitization had been acquired through the inhalation of dry dust resulting from the rabbit hair which was present in pillows, comfortables, toys, clothing and other articles.

In order to prove this hypothesis, we felt it necessary to produce in an animal a state of protein sensitivity through the direct inhalation of a dry animal emanation, and, further, to reproduce the symptom-complex of bronchial asthma.

MATERIALS AND METHODS USED  In approaching this work, we were confronted with the following considerations: first, the choice of an animal in which this mechanism could be reproduced; second, the necessity of reproducing the entire

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