Wahl,1 in his paper on neuroblastoma in 1914, stated that it was possible to recognize this particular tumor much more readily than previously. This advance he attributed to the extensive investigation of the development of the sympathetic nervous system. The number of cases reported has increased considerably during the last few years; the literature contains detailed and exhaustive studies of the development of the sympathetic system, as well as descriptions of the macroscopic and histologic appearance of tumors which affect it. We believe, however, that the present report is justified because of the comparative rarity of the tumor under discussion.
The diagnosis of "malignant neuroblastoma" is seldom made clinically. If we study the histories and records of the reported cases, as well as those of our own, we usually find the antemortem diagnosis of "sarcoma of the kidney" or "sarcoma of the liver." Pepper2 and Hutchinson3 have
KWARTIN B, TWISS JR. MALIGNANT NEUROBLASTOMA: REPORT OF THREE CASES. Am J Dis Child. 1927;34(1):61–71. doi:10.1001/archpedi.1927.04130190068004
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: