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August 1927


Author Affiliations

From the laboratories of the Subdepartment of Pediatrics, University of Toronto and of the Hospital for Sick Children, and the wards of the Hospital for Sick Children.

Am J Dis Child. 1927;34(2):218-233. doi:10.1001/archpedi.1927.04130200062009

PLAN OF INVESTIGATION  In those cases in which it was possible to study the complete salt metabolism, a plan similar to that outlined in a previous paper1 was followed. This, in brief, consisted of the careful determination of all sodium and chloride ingested and excreted during a three or four day period, following a preliminary period of three days on the same diet. Blood was withdrawn in the middle of the metabolism period. Complete balance experiments were not always possible, and in many such cases the daily excretion of chlorides and the effect of added sodium chloride on its excretion were studied. Such patients were always on "salt-free" diets consisting largely of milk at first, and later of vegetables, fruit, cereals and, later on, added protein. When figures for the intake are given in the latter cases, they represent approximate values only, obtained by computation of their amounts from