Five of the seven cases to be described were presented at the meeting of the American Pediatric Society, in 1925;1 the other two have come to our attention more recently. They have enough common and distinctive features to lead us to believe that they can be classed properly in the same group, and the patients present certain peculiar appearances, not especially noted heretofore in the literature of the anemias, which seem to us well worth recording.
The thing that first led us to distinguish these children was their peculiar appearance. They resembled the mongolian race distinctly. This characteristic, on analysis, proved to be due partly to a muddy, yellowish discoloration of the skin and partly to a thickening of the cranial bones and the malar eminences; the thickening was more pronounced when the progress of the disease had been more rapid in the earliest years. This peculiar appearance has
COOLEY TB, WITWER ER, LEE P. ANEMIA IN CHILDREN: WITH SPLENOMEGALY AND PECULIAR CHANGES IN THE BONES REPORT OF CASES. Am J Dis Child. 1927;34(3):347–363. doi:10.1001/archpedi.1927.04130210022002
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