Generalized edema associated with renal, cardiac and nutritional disease and with certain diseases of the blood is commonly recognized; the so-called angioneurotic edemas are also well known, but generalized edema not associated with any of the disorders mentioned is not so frequent and may even escape attention.
Constatt,1 in 1856, classified certain forms of hydrops not readily explained on the basis of the then known etiologic factors, as a manifestation of pathologic changes of the skin.
Wernich2 reported an interesting case in which a complete autopsy failed to reveal any pathologic change that might explain the cause of the edema.
In a comprehensive review, Wagner3 reported his observations in eight cases of generalized edema; six occurred in children ranging in age from 22 months to 12 years; three children recovered and three succumbed. The following symptoms occurred in his cases: The character of the onset of the
ROST WL. GENERALIZED EDEMA OF UNDETERMINED ETIOLOGY: REPORT OF AN UNUSUAL CASE. Am J Dis Child. 1927;34(5):773–778. doi:10.1001/archpedi.1927.04130230057007
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