The existence of human hypersensitiveness to various substances and its detection by means of protein skin tests are now established and generally accepted. The methods largely employed are the scratch and intradermal. The scratch (cutaneous or dermal) method was advocated by Schloss and Walker and the intradermal (intracutaneous) method by Cooke. These methods are so different in regard to technic and interpretation of reactions that the tendency has been to employ one method to the exclusion of the other. It is a moot question as to which method of testing is superior or more reliable, and considerable controversy has resulted.
The proponents of the intradermal method point to the fact that the Mantoux tuberculin test is more delicate than the cutaneous test of Pirquet, and also that the Schick test done by the intradermal method is more reliable and practical than when it is done by the scratch method. Schick,
PESHKIN MM, FINEMAN AH. ASTHMA IN CHILDREN: VI. A COMPARATIVE STUDY OF THE SCRATCH AND INTRADERMAL METHODS OF SKIN TESTING. Am J Dis Child. 1927;34(5):815–834. doi:10.1001/archpedi.1927.04130230099012
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