Since the publication of a previous communication on "Extinction Tests in Scarlet Fever,"1 many articles have appeared on the blanching effect of serum from patients convalescing from scarlet fever as compared to the blanching effect produced by the serums of animals or people who had been actively immunized by injection of (1) toxic filtrates, (2) the probable etiologic streptococcus of scarlet fever or (3) the injection of a combination of both toxic filtrate and dead bacteria.
As'troe and Constantinascu2 injected specimens of bloods from patients with scarlet fever into rabbits; six days later, a Schultz Charlton test of the withdrawn rabbits' serum was positive; eighteen days later, a more marked reaction occurred. Levin and Parsons,3 Birkhaug4 and Janovici5 among others, also showed that the serums obtained from actively immunized animals possessed blanching qualities.
The importance of the Schultz-Charlton phenomena lies in the fact that commercial antitoxin
TOOMEY JA. STUDIES IN SCARLET FEVER: SKIN BLANCHING BY COMMERCIAL ANTITOXINS. Am J Dis Child. 1928;35(4):607–614. doi:10.1001/archpedi.1928.01920220052005
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