In 1882, Hofmeier1 first suggested a hematogenous origin for jaundice of the new-born infant. For years this theory received little attention, but evidence gradually accumulated which led writers on the subject to grant it a rôle of minor importance, then to assign it a parity with hepatogenous factors, and finally to advance it as the sole cause of this condition.
In 1912, Hess2 dismissed blood destruction as being a primary cause of jaundice, on the following grounds: First, when the liver is extirpated, jaundice cannot be induced; second, the finding of bile acids in the pericardial fluid of jaundiced babies proves the participation of the liver; third, free hemoglobin cannot be found in the blood of the new-born infant; fourth, jaundice cannot be produced by the injection of hemoglobin, and fifth, jaundice does not follow transfusion. Today each of these objections can be met. Whipple and Hooper3
MITCHELL JM. THE RÔLE OF HEMOLYSIS IN JAUNDICE OF THE NEW-BORN INFANT. Am J Dis Child. 1928;36(3):486–501. doi:10.1001/archpedi.1928.01920270063007
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