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October 1928

THE DISTRIBUTION OF THE GLOBULIN AND ALBUMIN FRACTIONS IN THE BLOOD AND IN THE URINE IN NEPHROSIS: A PRELIMINARY REPORT

Author Affiliations

MINNEAPOLIS
From the Department of Pediatrics, University of Minnesota.

Am J Dis Child. 1928;36(4):756-763. doi:10.1001/archpedi.1928.01920280107009
Abstract

The chronic disease of the kidney known as nephrosis is now considered a distinct clinical entity. Davison and Salinger1 and others have demonstrated on autopsy material that the renal damage in nephrosis is largely tubular, and for this reason they suggest the use of the term tubular nephritis rather than the term nephrosis. It is not always easy to differentiate this condition from other forms of nephritis. A pure form of tubular nephritis is probably present only during the initial stage, and mixed forms occur as the disease progresses. Davison and Salinger1 pointed this out. Elwyn2 was of the opinion that cases of glomerular nephritis may, in course of time, merge into the tubular form. We have under observation at the present time a case in which just such a transition seems to be taking place.

The outstanding clinical features of tubular nephritis, apparently characteristic of only

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