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February 1929

TETANY IN INFANTS: A COMPARISON OF VARIOUS AGENTS USED IN TREATMENT

Author Affiliations

NEW YORK
From the Department of Diseases of Children, College of Physicians and Surgeons, Columbia University; the Children's Medical Division and Department of Pathology, Bellevue Hospital.

Am J Dis Child. 1929;37(2):311-322. doi:10.1001/archpedi.1929.01930020081008
Abstract

Numerous agents have been used in the treatment of infants with tetany. These may be divided into two groups: (1) substances which effect an immediate but transient rise in the serum calcium, for example, calcium chloride and parathyroid extract, and (2) those with a slower but more lasting effect, namely, ultraviolet radiant energy, irradiated cholesterol and irradiated ergosterol. It is our purpose in this paper to describe the effect of the second group of agents on the clinical manifestations and the serum calcium of infants with tetany.

ULTRAVIOLET RADIANT ENERGY  The curative effect of ultraviolet radiant energy on infants with tetany was first demonstrated by Huldschinsky1 in 1920. Similar results were obtained by Sachs.2 Hoag3 and Casparis and Kramer4 found that the clinical improvement following irradiation is accompanied by a rise in the calcium concentration of the serum from low tetanic values to normal. Kramer, Casparis

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