Within two years after Bordet and Gengou1 had grown their gram-negative, influenza-like bacillus on a special potato-blood-agar medium, Klimenko2 claimed to have produced whooping cough easily in four monkeys and ninety-six puppies by inoculation and by transmission from one animal to another. In 1912, Mallory, Hornor and Henderson3 dropped cultures into the nares of rabbits, puppies and three Rhesus monkeys. The monkeys remained well, but the rabbits became emaciated and developed signs of snuffles. A gram-negative bacillus was grown from the nares and trachea of the infected animals. Histologic studies revealed numerous gram-negative bacilli between the cilia of the trachea and larynx. The conclusion was that the experiments "supplied the steps which have heretofore been lacking, according to Koch's laws, for the complete demonstration that the Bordet-Gengou bacillus is the cause of whooping cough." In tests with dogs suffering from distemper, Galli and Valerio,4 in 1908,
SAUER LW, HAMBRECHT L. EXPERIMENTAL WHOOPING COUGH. Am J Dis Child. 1929;37(4):732–744. doi:10.1001/archpedi.1929.01930040041002
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: