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Case Reports
June 1929

CONGENITAL HEMOLYTIC ICTERUS: TREATMENT WITH SPLENECTOMY; REPORTS OF TWO CASES

Author Affiliations

INDIANAPOLIS
From the Medical Research Laboratories, Indianapolis City Hospital.

Am J Dis Child. 1929;37(6):1254-1259. doi:10.1001/archpedi.1929.01930060131018
Abstract

Numerous reports are found in the literature concerning the excellent results obtained with splenectomy in the treatment of familial hemolytic icterus.1 We observed two sisters with familial hemolytic jaundice for sixteen and a half months. During this time frequent examinations of the blood were made. Before splenectomy,2 the increased rate of production of red blood cells and the increased fragility of the red cells, associated with jaundice and a moderate degree of secondary anemia, were consistently present. Immediately following splenectomy, the blood bilirubin and the absolute number of reticulocytes (young red blood cells) returned to normal.

REPORT OF CASES  Case 1.—History.—On March 16, 1927, the younger sister, aged 5, was brought to the outpatient clinic following an indiscretion in diet. A definite icterus was observed and the abdomen was enlarged and tender. The time when icterus first became evident could not be ascertained. On March 26, 1927, the

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