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This extensive report gives the results of a close, sustained critical scrutiny of the general biology of the meningococcus, and of its reactions to its environment. The physiology in meningococcal infections, the virulence of the organism, the toxin and the immunity reactions are discussed in full detail. The author believes that contact with a person previously infected is the only source of infection. At least 95 per cent of all cases have not resulted from contact with patients having the disease, but from contact with "healthy carriers." A good bibliography has been appended.