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This book is a careful account of certain experimental work which has been done at Toronto, with an interpretation of the results. It is an excellent and clear exposition, simply written. The main thesis is that fat may be converted into carbohydrate in the internal metabolism. This is in direct opposition to Lusk's contention that such a conversion never occurs. The evidence given indicates that the foundations of the Lusk doctrine are not secure, and, further, it is strongly suggestive, though perhaps largely circumstantial, that this doctrine is incorrect. The evidence on both sides is carefully considered, and throughout is felt a constant appeal for more openmindedness on the part of the workers in this field and the necessity for new evidence to weigh. Perhaps the greatest value of the book is that it may serve as an antidote to dogmatic doctrines of metabolism which are stressed so much in