In infants, endogenous uric acid has been shown to be excreted in much larger amounts proportionately than in adults. This appears to be due, in part, at least, to the relatively larger amount of glandular tissue, which comprises nearly one half of the total body substance of the infant. Other factors, for example, the amount of protein ingested and possibly the amount of carbohydrate, which in the adult has been shown to stimulate cellular metabolism, may have some influence. Roughichitch suggested that in the artificially fed infant the excretion of high amounts of uric acid may be the result of the proportionately high intake of protein, although in his recent study he did not find a close relationship between the urinary nitrogen and uric acid.2 Orgler3 believed that the lower output of uric acid of the breast-fed infant is due to the better utilization of the ingested food.
DANIELS AL, HEJINIAN LM. GROWTH IN INFANTS FROM THE STANDPOINT OF PHYSICAL MEASUREMENTS AND NITROGEN METABOLISM: III. URIC ACID. Am J Dis Child. 1929;38(3):507–512. doi:10.1001/archpedi.1929.01930090059007
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