The first case of agranulocytosis observed in Japan was diagnosed in a Japanese boy, aged 4 years and 1 month, as a result of a routine white cell count. The method of making the count was that of Sato and Shoji,1 which differentiates lymphoid and myeloid cells. Because of apparent sepsis, a predominance of myeloid cells (blue-stained) was expected, but only lymphoid cells (red-stained) were found.
REPORT OF CASE
History.—S. Murakami, a boy, aged 4 years and 1 month, had been vaccinated and had had measles and whooping-cough. The parents and the other children were in good health. On Nov. 6, 1925, he was run over by an automobile and sustained a wound in the head as large as the palm. In spite of immediate surgical treatment, the wound suppurated and he had high fever. On December 22, he was admitted to the Surgical Department of the Hospital
TOKUE K, YASUMOTO M. AGRANULOCYTOSIS. Am J Dis Child. 1929;38(5):1037–1043. doi:10.1001/archpedi.1929.01930110136017
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