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February 1930


Author Affiliations

From the Department of Pediatrics, Marquette University, and the Milwaukee Children's Hospital.

Am J Dis Child. 1930;39(2):294-297. doi:10.1001/archpedi.1930.01930140056007

A review of the literature on the prevention of measles was reported in July, 1928.1 At this time there were presented the results of the prophylactic inoculation with antimeasles diplococcus serum (Tunnicliff) of children exposed to measles. Thirty-one of thirty-four children inoculated on or before the fifth day after exposure did not develop measles. Three children inoculated on or before the fifth day developed the disease in a modified form.

Other favorable reports have appeared concerning the use of Tunnicliff's serum since my previous publication on this work. Halpern reported twenty-eight of forty-five patients, or 63 per cent, successfully protected.2 Hoyne considered the serum a reliable prophylactic if given within three days after exposure.3 Hoyne and Peacock reported forty-three children inoculated within four days after exposure who did not develop the disease; thirty-eight children inoculated on the fifth day or later developed the disease, but in 81.5