In 1893, George Dock1 published his first report of a case of chloroma. At this time, he was able to find reports of only sixteen similar cases in the literature, the first one being by Burns2 in 1823. As Dock pointed out in his most interesting report, it was von Reckling-hausen, in 1885, who first suggested the close relationship between chloroma and leukemia. In 1904, Dock and Warthin3 summarized twenty-one cases reported in the literature from 1893 to 1904. They found the following important facts: (1) males were affected more frequently than females; (2) the ages of the patients ranged from 10 months to 52 years, with a majority in early life; (3) the duration of the disease varied from one to eighteen months; (4) the head was affected in all but two cases, and (5) the marrow of the long bones was involved in seven of
WASHBURN AH. CHLOROMA: REPORT OF A CASE WITH RECOVERY FOLLOWING ROENTGENOTHERAPY, WITH A REVIEW OF THE LITERATURE. Am J Dis Child. 1930;39(2):330–348. doi:10.1001/archpedi.1930.01930140092011
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