Enlargement of the heart in infancy and in childhood, without any anatomic basis, has been described under the terms of idiopathic cardiac hypertrophy, dilatation or enlargement. A close review of some of the cases reported under these various headings reveals the fact that not all of the cases can be called idiopathic, because of the presence of renal lesions in some and of coarctation of the aorta in others. More careful microscopic examination of the heart also revealed the presence of lymphocytic infiltrations in the myocardium itself. Cases have also been reported with myocardial round cell infiltration in association with status thymicolymphaticus (Ceelen,1 Blühdorn2), while other cases have been reported in which status thymicolymphaticus or thymic enlargement was present in addition to the cardiac enlargement without myocardial round cell infiltration (Oberndorffer,3 Howland4). There remains, however, a group of cases in which the only pathologic change is
STEINER M, BOGIN M. IDIOPATHIC CARDIAC ENLARGEMENT ASSOCIATED WITH STATUS THYMICOLYMPHATICUS. Am J Dis Child. 1930;39(6):1255–1260. doi:https://doi.org/10.1001/archpedi.1930.01930180105009
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