Seven or eight years ago, an infant about 1 year of age entered the Children's Memorial Hospital showing the clinical picture of acute sepsis, with high fluctuating temperature, yellowish color, slightly enlarged spleen and a fairly abundant crop of petechiae. Immediately after admission, the child was presented at a postgraduate clinic by one of us (J. B.) as having severe sepsis of unknown origin. The blood count, however, revealed marked anemia and still more marked leukopenia, with an almost complete absence of polymorphonuclear cells. The diagnosis was changed to that of an aleukemic stage of acute lymphatic leukemia, and the case, as was expected, went on to a rapidly fatal termination, with an ever-increasing exacerbation of all the cardinal symptoms. The history of this case, unfortunately, cannot be found, and so the exact details are not reportable. It made, however, a deep impression, as we had never encountered the much
BIGLER JA, BRENNEMANN J. SEPSIS WITH LEUKOPENIA (AGRANULOCYTOSIS) IN CHILDREN: REPORT OF TEN CASES. Am J Dis Child. 1930;40(3):515–532. doi:10.1001/archpedi.1930.01940030053007
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