The injection of dextrose parenterally has become a recognized therapeutic measure, notwithstanding the fact that at times its administration is followed by unpleasant reactions. Williams and Swett,1 in a series of studies on the hydrogen ion concentration of various fluids commonly administered intravenously, found that the PH of a solution of dextrose became acid on autoclaving, and they attributed the untoward reactions to the injection of this fluid. The same authors, in conjunction with Mellon, Slagle and Acree,2 advocated the addition of buffer solutions to the autoclaved dextrose as a means of maintaining a neutral solution. This method has been widely adopted, and the results following the use of solutions so prepared seem quite satisfactory. However, the preparation of the buffer salts is a laborious and time-consuming task and has been relegated to those commercial laboratories that supply buffer salts with ampules of 50 per cent dextrose
SCHWENTKER FF. THE PREPARATION OF DEXTROSE FOR PARENTERAL INJECTION. Am J Dis Child. 1930;40(3):533–535. doi:10.1001/archpedi.1930.01940030071008
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