Clinical experience has fully established the antiketogenic effect of insulin in cases of diabetic ketosis, but the action of insulin in ketosis of nondiabetic origin is more uncertain. In adults living on a ketogenic diet, Herzberg1 and Thannhauser and Mezger2 found a decrease in ketosis after the administration of insulin. On the other hand, Burn and Ling3 found an increase in ketonuria in fasting rats after the administration of insulin. In normal rabbits, Collip4 has demonstrated that insulin can give rise to ketonuria, when the blood sugar falls as low as 0.065 and 0.045. Mainzer5 has seen that insulin shock in diabetic patients may be accompanied by an increased excretion of ketone bodies. According to investigations made by Freise and his co-workers in children with alimentary and diabetic ketosis,6 the antiketogenic action of the insulin arises only when the organism has a certain surplus
SALOMONSEN L. EFFECTS OF INSULIN AND EPINEPHRINE ON THE BLOOD ACETONE IN FASTING CHILDREN. Am J Dis Child. 1930;40(4):718–724. doi:10.1001/archpedi.1930.01940040015002
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