In a previous communication, we1 attempted to give partial answers to two questions: 1. Is a positive skin reaction to tuberculin an absolute indication of tuberculous infection? 2. Is there ever absence of the tuberculin skin reaction in patients infected with the tubercle bacillus?
From a review of the literature and our own studies, certain conclusions were reached which may be stated briefly as follows: A positive reaction of the skin to tuberculin is approximately two to four times as frequent during the convalescent afebrile stage as during the acute stage of such diseases as measles, diphtheria, scarlet fever, varicella, poliomyelitis, pneumonia, influenza, gastro-enteritis, etc. There is some evidence that larger doses of tuberculin may cause a positive skin reaction to occur during the febrile stage of these diseases. Readings of skin tuberculin reactions during acute diseases should be continued for several days, as the skin response may be
EDDY B, MITCHELL AG. STUDIES IN IMMUNITY: II. THE EFFECT ON THE SKIN TUBERCULIN REACTION OF NONSPECIFIC FACTORS. Am J Dis Child. 1930;40(4):771–775. doi:10.1001/archpedi.1930.01940040068006
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