The pathognomonic significance of a diminished inorganic phosphate content of the blood of rachitic infants was demonstrated by Park and Howland1 in 1920 and by Howland and Kramer2 in 1921. The results of their investigations have been confirmed by both clinicians and laboratory workers, so that it is known that a decrease in the inorganic phosphates of the blood accompanies the onset and parallels the development of infantile rickets, and that an increase in the phosphate salts attends the healing of the rickets, regardless of whether or not this healing process is brought about by natural sunlight, ultraviolet light irradiation (Hess and Gutman3), cod liver oil or viosterol. Howland and Kramer4 later offered evidence to show that the product obtained by multiplying the value for the calcium of the blood by that of the phosphorus offers a better criterion in judging the severity of the rachitic
COMPERE EL. THE EFFECT OF PHOSPHORUS IN RICKETS: II. CHEMICAL CHANGES IN THE BLOOD IN RICKETS FOLLOWING ADMINISTRATION OF PHOSPHORUS. Am J Dis Child. 1930;40(6):1177–1192. doi:10.1001/archpedi.1930.01940060017002
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