The search for the etiology of the various forms of osteochondritis has led some authors to believe that rickets is a causative factor. Clinical and roentgenologic studies,1 however, have failed to substantiate this assumption. A review of the literature shows that the few desultory studies on the inorganic blood chemistry, based on a limited number of cases, have given conflicting results.
Seldowitz and Zimtbaum2 concluded that their study of the inorganic composition of the blood, that the efficacy of antirachitic therapy in their single case of Koehler's disease of the tarsal scaphoid and that the histologic evidence of osteoid tissue and irregular calcification gleaned from the literature pointed toward the rachitic nature of the disease. Durham and Outland,3 in a study of six cases of Perthes' disease and one case each of apophysitis of the os calcis and of Osgood-Schlatter's disease, concluded: (1) that Perthes' disease is
BUCHMAN J, GITTLEMAN IF. INORGANIC BLOOD CHEMISTRY IN THE OSTEOCHONDRITIDES. Am J Dis Child. 1930;40(6):1250–1261. doi:10.1001/archpedi.1930.01940060090008
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