[Skip to Navigation]
Other Articles
April 1931

DIGITALIS: ITS VALUE IN THE TREATMENT OF CHILDREN WITH RHEUMATIC HEART DISEASE

Author Affiliations

NEW YORK
From the Departments of Pediatrics and Medicine, New York University, and from the Children's Medical Service and Third (New York University) Medical Division, Bellevue Hospital.

Am J Dis Child. 1931;41(4):801-815. doi:10.1001/archpedi.1931.01940100057008
Abstract

Before the value of a drug can be determined in the relief of a symptom or symptoms or in the curing of a disease, certain facts as to dosage and method of administration must be ascertained, and controlled methods of study must be instituted. This is particularly true of a drug like digitalis, in which the dosage, the rate of absorption and the rate of elimination can be studied only biologically.

Almost none of these facts were known about digitalis until 1915. During that year Eggleston1 showed that in adults with heart failure, the average dose in terms of milligrams of powdered leaf is 0.15 cat unit2 per pound of body weight. He stated that this was an average, and that there is an average range of approximately 15 per cent above and below. Some of his cases showed a much higher, others a much lower, variation. Pardee

Add or change institution
×