The natural history of rheumatic fever in children is characterized by the repeated recurrence of its many and varied manifestations of activity over a period of years. From the onset until the patient is about 12 years of age there is apparent an increasing susceptibility and after this age a diminishing susceptibility.1
If the conception of rheumatic fever is accepted as an allergic or hyperergic phenomenon, and if it is assumed that the many manifestations of activity are due to a state of hypersensitivity of the tissues to some component of streptococci, the period before 12 years may be considered one of predominant hypersensitiveness to streptococci and the period after 12 years as one of gradually increasing hyposensitiveness, possibly due to autodesensitization. It would then seem reasonable to attempt to induce a state of hyposensitiveness during the period of increasing susceptibility. Therefore it was considered worthwhile to attempt to
WILSON MG, SWIFT HF. INTRAVENOUS VACCINATION WITH HEMOLYTIC STREPTOCOCCIITS INFLUENCE ON THE INCIDENCE OF RECURRENCE OF RHEUMATIC FEVER IN CHILDREN. Am J Dis Child. 1931;42(1):42–51. doi:10.1001/archpedi.1931.01940130049003
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