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July 1931

LIPOID HISTIOCYTOSIS: (NIEMANN-PICK'S DISEASE)

Author Affiliations

CHICAGO
From the Departments of Pediatrics and Pathology of the Research and Educational Hospital and University of Illinois College of Medicine.

Am J Dis Child. 1931;42(1):77-87. doi:10.1001/archpedi.1931.01940130084007
Abstract

In recent years, in fact during the past five years, thirteen of the seventeen reported cases of lipoid histiocytosis (Niemann-Pick's disease) have been recorded.1 While the disease is rare and pathologically presents a most striking picture, it seems incredible that it is a new condition. Since the first description appeared in the literature,2 there have been subsequent reports by other authors whose clinical, chemical and pathologic studies have been comprehensive and complete. These reports, together with the work of Rowland3 who attempted to correlate the various clinical manifestations of disturbed lipoid metabolism, have contributed greatly to the understanding of this subject. In view of these contributions, the report of the following case is of interest.

REPORT OF CASE  History.—A. S., a Jewish boy, aged 18 months, was admitted to the hospital on April 21, 1929. The complaints on entrance were failure to gain properly since birth,

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