The purpose of this study was to determine the effects of digitalis on the edema of children with rheumatic fever and chronic valvular heart disease in the presence of normal sinus rhythm.
This form of therapy for children was strongly advocated by Jacobsen and Davison,1 who studied a series of twenty-six children with "severe cardiac decompensation" in the pediatric wards of the Johns Hopkins Hospital. In their cases, symptoms and signs of cardiac disease had been present from three to thirty months before decompensation developed. Sixteen of the children were given various amounts of digitalis during their stay in the hospital. The others were used as controls. All were orthopneic and edematous, and half of them had marked ascites.
During the first twenty-four hours, Jacobsen and Davison gave an amount of digitalis per pound of body weight approximately 50 per cent greater than that generally given to adults if
SCHWARTZ SP, LEVY J. DIGITALIS STUDIES ON CHILDREN WITH HEART DISEASE: IV. THE EFFECTS OF DIGITALIS ON THE EDEMA OF CHILDREN WITH RHEUMATIC FEVER AND CHRONIC VALVULAR HEART DISEASE IN THE PRESENCE OF SINUS RHYTHM. Am J Dis Child. 1931;42(6):1349–1363. doi:10.1001/archpedi.1931.01940190070004
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