Anemia is a common manifestation of infectious invasion in infancy and childhood. It appears abruptly with the sudden onset of an acute infectious disease like diphtheria or develops gradually as a result of chronic infection in the child's body. Anemia may appear as the first striking clinical expression of a chronic focus of infection like sinusitis. While anemia as a systemic injury by infection is not always discernible, its correction is indispensable in effective recovery. Clinical observations of the varied responses on the part of infants and children to therapeutic procedures instituted in the course of infection or during convalescence have led us to raise a number of questions regarding the anemias associated with infection. How do various infections actually produce anemia? Is the severity of infection directly related to the resulting degree of anemia? Does infection injure the blood-forming tissues or their products in the circulating blood? Are the
KUGELMASS IN, LAMPE M. THE MECHANISM OF ANEMIA ASSOCIATED WITH INFECTION IN INFANCY AND IN CHILDHOOD. Am J Dis Child. 1932;43(2):291–305. doi:10.1001/archpedi.1932.01950020023003
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