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Botticelli, Sandro, or Alessandro di Mariano dei Filipepi (1444-1510), has contributed a number of things to pediatric art. His painting of the Virgin and the Child and St. John in the Dresden Gallery is a good example of rickets. Nearly all the bambinos of early Italian art show signs of this disease, from which one may infer that rickets was rather general at the time the pictures were painted. Here one sees the swellings of the wrists and ankles well marked.