LIPOID HISTIOCYTOSIS (NIEMANN-PICK TYPE)

The pathology of disturbances of lipoid and fat metabolism is not yet clearly understood. At the present time, a separation of three distinct types, Niemann-Pick, Gaucher and Schüller-Christian, seems justified.¹ In this report, two additional cases of the Niemann-Pick type are presented with comments on their significance in the general problem of this type of disease. The histology has recently been reviewed by Bloom² and the chemistry by Sobotka, Epstein and Lichtenstein.³

REPORT OF CASES  Case 1.—History.—A white girl, aged 15 months, of gentile parentage, was admitted to St. Elizabeth Hospital on July 20, 1929, with the complaint of loss of weight and irritability. Enlargement of the abdomen had been observed by the mother for the past six months. The patient was the fourth full term child, with a birth weight of 9 pounds (4082.33 Gm.). When the infant was 3 months of age, breast