The acid-base equilibrium of new-born infants has proved a fertile field for research. Interesting differences exist between the new-born infant and the adult. In the first paper of this series, Hoag and Kiser1 showed that the serum of the new-born infant has a lower carbon dioxide content and a higher chloride content than that of the normal adult. Other authors have reported similar decreases in the carbon dioxide content of the serum. Kane and Kreiselman2 found an average value of 47.7 per cent by volume for the carbon dioxide content in the cord blood of forty-seven infants. Leenhard and Chaptal3 demonstrated that there is a decrease in the bicarbonate of the blood of young infants. Halfer4 found a latent acidosis in the new-born infant as manifested by a decrease in the carbon dioxide content of the blood, which usually persisted during the first two weeks of
MARPLES E, LIPPARD VW. ACID-BASE BALANCE OF NEW-BORN INFANTS: II. CONSIDERATION OF THE LOW ALKALINE RESERVE OF NORMAL NEW-BORN INFANTS. Am J Dis Child. 1932;44(1):31–39. doi:10.1001/archpedi.1932.01950080041005
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