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This book brings the various discussions on vaccination against diphtheria together in one volume. It contains a history of the early researches and an analytic study of the physical and biologic properties of toxin-antitoxin as compared to anatoxin. The methods of administration of anatoxin and the possible reactions and epidemic study are well discussed. It is of interest to note that the author does not believe in inoculations of anatoxin before the end of the first year, the ideal time being from this period to the sixth year. He believes that the subcutaneous introduction is the only advisable method. Three injections are the method of choice, of 1, 1.5 and 1.5 cc. The total time of injections should be three weeks, that is, nine days between the first and second injection, and twelve days between the second and third. These are minimum intervals; less than this diminishes the effect, while
La vaccination contre la diphtérie. Am J Dis Child. 1932;44(4):914. doi:10.1001/archpedi.1932.01950110216021
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